The toxicity of 1-Butanol
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The toxicity of 1-Butanol
1-Butanol is readily absorbed through the intestinal tract and lungs, and also to some extent through the skin. It is metabolized completely in vertebrates in a manner similar to ethanol: alcohol dehydrogenase coverts 1-Butanol to butyraldehyde; this is then converted to butyric acid by aldehyde dehydrogenase. Butyric acid can be fully metabolized to carbon dioxide and water by the β-oxidation pathway, of which it is naturally the penultimate step. In the rat, only 0.03% of an oral dose of 2000 mg/kg was excreted in the urine.
The acute toxicity of 1-Butanol is relatively low, with oral LD50 values of 2290
The acute toxicity of 1-Butanol is relatively low, with oral LD50 values of 2290