The Uses Of Nicotinamide In Medicine 2

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hanlin
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The Uses Of Nicotinamide In Medicine 2

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Nicotinamide is an activator of sirtuins (but inhibits at higher doses) and has been reported to restore cognition in Alzheimer's disease transgenic mice.A safety study of niacinamide for the treatment of Alzheimer's disease is currently underway at the University of California, Irvine.
Nicotinamide has been reported to increase the endurance of mice.
Nicotinamide prevents immunosuppression caused by UVA and UVB radiation, and could be added to sunscreen.
Nicotinamide has been reported to be an effective skin whitener in topical application.
Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.[13] PARP-1 appears to be an important target for triple negative breast cancers because the cells are sensitive to inhibition of PARP-1.Niacinamide is also used by some patients in combination with intravenous vitamin C therapy for cancer.
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