Basic information of Nicotinamide

Lab equipments, tests, PVT ........etc
Post Reply
team2012
Posts: 7
Joined: Tue Jul 26, 2011 11:31 am

Basic information of Nicotinamide

Post by team2012 »

Nicotinamide , with CAS number of 98-92-0, can be called Niamide ; Niacinamide/Nicotinamide ; Austrovit PP ; beta.-Pyridinecarboxamide ; Nikotinsaeureamid ; Amid kyseliny nikotinove ; Nicotinamidum ; Pyridine-3-carboxylic acid amide ; Nikotinsaeureamid ; Nicotinamide(Vitamin B3) ; a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- ; 3-Pyridinecarboxamide ; Nicotinamida ; Niacinamide ; 3-Pyridinecarboxylic acid amide ; Nicotine acid amide . Nicotinamide, also known as niacinamide and Nicotinic acid amide, is the amide of Nicotinic acid (vitamin B3). It is a water-soluble vitamin and is part of the vitamin B group.Nicotinic acid(also known as niacin)can be converte to niacinamide in vivo. It is a white to off white powder.

For production of niacinamide (CAS NO.) in the past, methylethylpyridine was oxidized with nitric acid to yield niacin, and β-picoline was treated with air and ammonia to produce the nitrile that was then hydrolyzed to niacin-amide. A more modem process can produce both niacin and niacinamide (CAS NO.98-92-0) from a single feedstock, either β-picoline or 2-methyl-5-ethylpyridine by oxidative ammonolysis, a combination of oxidation and amination.
Either niacin or niacinamide (CAS NO.98-92-0) can be selectively isolated from the hydrolysis by varying the hydrolysis time and nitrite concentration. A higher hydrolysis temperature favors production of niacin.

Niacinamide (CAS NO.98-92-0) is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics, it is also an inhibitor of sirtuins and has been reported to restore cognition in Alzheimer's Disease transgenic mice, also has been reported to be an effective skin whitener in topical application.
Post Reply