The toxicity of 1-Butanol

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qiuranxuan
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Joined: Tue Jul 12, 2011 3:13 pm

The toxicity of 1-Butanol

Post by qiuranxuan »

1-Butanol is readily absorbed through the intestinal tract and lungs, and also to some extent through the skin. It is metabolized completely in vertebrates in a manner similar to ethanol: alcohol dehydrogenase coverts 1-Butanol to butyraldehyde; this is then converted to butyric acid by aldehyde dehydrogenase. Butyric acid can be fully metabolized to carbon dioxide and water by the β-oxidation pathway, of which it is naturally the penultimate step. In the rat, only 0.03% of an oral dose of 2000 mg/kg was excreted in the urine.
The acute toxicity of 1-Butanol is relatively low, with oral LD50 values of 2290
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